CONTRIBUCION AL ESTUDIO DE LA ACCION FARMACODINAMICA DE LOS PRINCIPIOS ACTIVOS DEL CHILE

Resumen

The pharmacodinamical study of capsicin shows that this substance has little toxicity even in large doses : that it has marked irritating action on the skin and on the mucous membranes. It evokes the flow of saliva in dogs. It does not have a marked action on the gastric secretion; on the other hand it excites gastric and intestinal movement in man and in the animals of the laboratory.
It acts also as an exciting factor on che contraction of the isolated uterus of the guinea-pig. It brings about a negative inotropism in the heart of frogs, followed by a positive phase which is not very intense bue persistant. It does not bring about a change in the cardiac rhythm. A large intervenal dose produces a fall in the arterial tension of dogs. It has a variable action on the respiration according to the doses used, but in general brings about tachypnea and increases in the size of the respiratory movements.
Prolonged ingestion of capsicin causes in the laboratory animals kidney lesions that consist in the desquamation of the convoluted tubes and small intertubular hemorrages.
The study of the Vitamine content showed the existance of the following, A B and C; the rest are yet to be investigated .